Invited speakers

• Albin Sandelin, Copenhagen University, Denmark
• Alena Shkumatava, Institut Curie, France
• Artemis Hatzigeorgiou, University of Thessaly, Greece
• Bart Deplancke, SIB & EPFL, Switzerland
• Christina Leslie, MSKCC, USA
• Erik van Nimwegen, SIB & University of Basel, Switzerland
• Ewa Szczurek, University of Warsaw, Poland
• Fran Supek, IRB Barcelona, Spain
• Jose Luis Gomez Skarmeta, University Pablo Olavide, Spain
• Julien Gagneur, TU Munich, Germany
• Martin Vingron, Max Planck Institute, Germany
• Nicholas Luscombe, UCL and Francis Crick Institute, UK
• Nikolaus Rajewsky, Max Delbruck Center for Molecular Medicine and Charite, Germany
• Paul Flicek, EBI, UK
• Peter Kharchenko, Harvard Medical School, USA
• Raluca Gordan, Duke University, USA

Meeting Program

Thursday Mar 15

18:00 – 22:00      Arrival and Registration

19:00                     Dinner at the Hotel

Friday Mar 16     Morning Session

08:30-10:15         Session 1: Epigenetics and Transcriptional Regulation

Valentina Boeva: Getting insights into cancer biology using the analysis of epigenetic data

Erik van Nimwegen: Inferring epigenergy landscapes from single-cell RNA-seq data

Peter Kharchenko: Exploring human brain with single-cell transcriptional and epigenetic measurements

10:15-10:35         Coffee break

10:35-12:00     Session 2: Design Principles and Evolution of cis-Regulatory Modules and Networks

Paul Flicek: Evolution of mammalian tissue specific transcriptional regulation

Jose Luis Gomez Skarmeta: Evolution of regulatory landscapes

Masa Roller*: Tissue-specific enhancer and promoter evolution in mammals

Friday Mar 16     Evening Session

16:30-17:30         Coffee and snacks – posters

17:30-19:45       Session 3: Sequence, Structure and Function of Enhancers and Promoters

Martin Vingron: Epigenetic networks, enhancer recognition and differential enhancers

Philipp Bucher: Structure and Evolution of Eukaryotic Core Promoter Elements

René Dreos*: Comparative analysis of core promoter elements using an EM algorithm

Uwe Ohler: Determinants of transcription directionality across metazoans

Dubravka Vucicevic*: Functional dissection of enhancers involved in neurogenesis using CRISPR/Cas9                                               

Christ Leemans*: Mechanisms of gene regulation in lamina - associated domains

20:00                     Dinner at the Hotel

Saturday Mar 17 Morning Session

08:30-10:15        Session 4: Regulation of Gene Expression by Signaling Pathways and RNA

Denis Thieffry: Synergy between T cell receptor and Toll-like receptor 5 signalling for CD4+ T cell activation

Tamar Juven-Gershon: Drosophila TBP-related factor 2 is a unique basal transcription factor that drives the expression of multiple target genes to regulate cell cycle progression and viability

Nikolaus Rajewsky: Single Cell Approaches for Understanding Gene Regulation by RNA

10:15-10:35         Coffee break

10:35-12:00      Session 5: Modeling the Evolution and Consequences of Regulatory Mutations in Human                  Disease

Albin Sandelin: The promoter- and enhancer landscape of inflammatory bowel disease

Fran Supek: Cancer genomes reveal clustered mutation signatures of error-prone DNA repair in active chromatin

Juan J. Tena*: Uncovering novel targets for p63-related hereditary malformations

Saturday Mar 17 Evening Session

16:30-17:30         Coffee and snacks – posters

17:30-19:45       Session 6: Experimental Characterization and Computational Modeling of Regulatory             interactions

Raluca Gordan: New insights into protein-DNA recognition: binding specificity to mispaired DNA, and divergence in specificity within transcription factor families

Bart Deplancke: Understanding human molecular variation using variable chromatin modules

Ewa Szczurek: Generalizations of linear effects models of signaling pathways from combinatorial perturbation data

Carl Herrmann*: Deciphering programs of transcriptional regulation by combined deconvolution of multiple omics layers

20:00                     Dinner at the Hotel

Sunday Mar 18 Morning Session

08:30-10:15        Session 7: Transcription Initiation and Regulatory RNAs

Boris Lenhard: Turnover of genomic regulatory blocks and evolution of long-range regulation

Alena Shkumatava: Dissecting the in vivo functions and mechanisms of action of lncRNAs

Artemis Hatzigeorgiou: Revisiting CAGE data analysis using structural information and machine learning

10:15-10:35         Coffee break

10:35-12:00    Session 8: Multi-level Genomic Regulation by DNA-binding Transcription Factors

Julien Gagneur: Proteogenomic characterization of human tissues reveals mRNA motifs controlling protein abundance

Pierre-Antoine Defossez: Mechanisms and functions of mammalian proteins that bind methylated DNA

Jake Yeung*: Chromatin interactions and transcription factor activity rhythms orchestrate circadian gene expression across organs

* Talks from selected abstracts

Participants:

• Alexander Kel
• Aziz Khan
• Bartek Wilczynski
• Carl Herrmann
• Christ Leemans
• Dubravka Vucicevic
• Jake Yeung
• Jonas Ibn-Salem
• Juan J. Tena
• Martin Burkert
• Masa Roller
• René Dreos
• Stephany Orjuela
• Swann Floc'hlay
• Tobias Zehnder
• Touati Benoukraf
• Vsevolod Makeev

Organizers

• Boris Lenhard, Imperial College London, UK
• Philipp Bucher SIB & EPFL, Switzerland
• Tammy Juven-Gershon, Bar-Ilan University, Israel
• Uwe Ohler, Max Delbrück Center, Germany
• Valentina Boeva, Inserm & Institut Cochin, France